Laura Taggart-Murphy (Bartholomew Lab; Microbiology) investigated host immune response to the myxozoan parasite Ceratonova shasta in salmon and trout.  Specifically, she was interested in the adaptive immune response in mucosal tissues as measured by lgT levels.  IgT is an antibody found mainly in mucosal tissues (gut, skin) and is analogous to mammalian IgA.  By depleting IgT-producing B-cells the fish, more was learned about the role of this antibody against infection with different genotypes of C. shasta.  Some genotypes of C. shasta result in high mortality (e.g., genotype I and II) whereas infection by genotype 0 rarely results in death.  These studies illustrated that increased levels of pro-inflammatory cytokines in genotype II infections may contribute to inflammation whereas less inflammation in genotype 0 infections may allow parasites to persist for years.  IgT depletion decreased pathogen load and the adaptive immune response may not protect against mortality from C. shasta.