Professor JoAnn Leong and Mark Engelking conducted much of the foundation work to develop the only approved DNA vaccine against Infectious Hematopoietic Necrosis Virus (IHNV). IHNV is one of the most destructive pathogens of salmon and trout in the Pacific Northwest. The virus is transmitted via direct contact or via a contaminated water source through mucus, feces, urine, and sperm. Signs of infection include swollen abdomen, anemia, and hemorhaging near the fins and mouth. Glycoprotein from the isolated wild-type iHNV was purified and provided substantial protection to rainbow trout and Kokanee (O. nerka) against IHNV.
Engelking, H.M., and Leong, J.C. 1989. The glycoprotein of infectious hematopoietic necrosis virus elicits neutralizing antibody and protective responses. Virus Research, 13(3):213-230.
Alsonso, M. and Leong, J.A. 2013. Licensed DNA vaccines against infectious hematopoietic necrosis virus (IHNV). Recent Pat. DNA Gene Seq 7(1):62-65.