Dr. Thomas Chen and Professor Chun-Mean Lin (U. of Connecticut) successfully demonstrated that several families of transgenic rainbow trout, which harbor the antimicrobial peptide cercropin P1 gene, are highly pathogen resistant.  Disease outbreaks caused by pathogen infection is one of the most serious bottlenecks in the aquaculture industry worldwide.  Traditional strategies including vaccination, antibiotics and selection of disease resistant fish strains by traditional approaches have been used to control fish diseases.  However, these strategies can have high economic costs, can lead to selection of antibiotic-resistant pathogens and still a lack of effective cures for viral infections remains.  Resistance to these disease agents can be promoted through selective breeding and transgenic fish technology.

Chiou, P., Chen, M., Lin, C.M., Khoo, J., Larson, J., Holt, R., Leong, J.A., Thorgaard, G., and Chen, T.T.  2014.  Production of homozygous transgenic rainbow trout with enhanced disease resistance.  Marine Biotechnology, 16(3):299-308.

Han, Y., Lin, C., and Chen, T.T.  2018.  RNA-Seq analysis of differentially expressed genes relevant to innate and adaptive immunity in cecropin P1 tansgenic rainbow trout (Oncorhynchus mykiss).  BMC Genomics 19:760.